Low hematocrit and hemoglobin and nutritional deficit

Percent transferrin saturation (normal % transferrin saturation = 20% to 50%).

Transferrin: Serum Transferrin level is needed for the D/D of the anemia.

It should be done along with serum iron to evaluate the % saturation for the diagnosis of iron deficiency anemia.

It helps in the differential diagnosis of anemias.

Total iron-binding capacity (TIBC = Normal = 250 to 450 Вµg/dL).

This also helps to evaluate the acute iron toxicity in children.

It should be measured along with TIBC for evaluation of iron deficiency.

It differentiates between hemochromatosis and hemosiderosis.

Serum total iron helps in the diagnosis of anemia.

This has no value in patients without anemia.

RDW is more sensitive to the differentiation of the microcytic anemia than the macrocytic RBCs cause.

Red cell distribution width (RDW)В helps to classify the anemia with the help of MCV.

This is better to evaluate hypochromasia than MCH.

MCHC is also instrumental calibration, and changes occur very late in the iron-deficiency anemia when anemia is very severe.

MCH has limited value in the differential diagnosis of anemias.

The patientвЂ™s detailed clinical history for diagnosis, physical examination, signs, and symptoms with the following lab workup.

Routine workup of the patient with anemia needs:

If normal, then advise electrophoresis.

If the above two tests are low, advise Ferritin and Bone marrow examination.

This is useful for the screening of occult alcoholism.

MCV is a better choice to classify the anemias and their differentiation.

Reticulocyte count was normal at 0.5 to 1.5%.

Hematocrit when it is less than 36 to 41%.

Hemoglobin when it is less than 12 to 13 G/dL.

Laboratory Criteria for the diagnosis of Anemias:

Bone marrow failure by chemotherapy or cancer infiltrates.

О±1ОІ1 and О±2ОІ2 globin stabilize the molecule.ДЄnemia classification: Anemia may be classified roughly based on Hb level:Дifferentiating points of various anemias: Characteristics findings.

This main function is with the help of hemoglobin (Hb) molecules, as the Hb molecule load and unload the O2.

When the O2 is unloaded, the ОІ-chain of Hb has pulled apart, permitting the entry of the metabolites 2,3-DPG resulting in a lower affinity of the molecule for O2.

This is dependent upon the 2,3-diphosphoglycerate (2,3-DPG).

The RBCs carry O2 from the lung to the tissue and bring CO2 in the venous blood to the lung.

Role of hemoglobin in O2 transport (Hb/O2 dissociation curve): Rochester (NY): University of Rochester Medical Center c2017.

University of Rochester Medical Center.

Department of Health and Human Services What To Expect with Blood Tests. National Heart, Lung, and Blood Institute.

Department of Health and Human Services What Is Polycythemia Vera?. Department of Health and Human Services What Are the Signs and Symptoms of Anemia?. Department of Health and Human Services What Are the Risks of Blood Tests?.

Department of Health and Human Services Types of Blood Tests. Department of Health and Human Services NCI Dictionary of Cancer Terms: hematocrit. Washington D.C.: American Association for Clinical Chemistry c2001вЂ“2017. Mayo Foundation for Medical Education and Research c1998вЂ“2017. Philadelphia: Wolters Kluwer Health, Lippincott Williams & Wilkins c2014. Brunner & Suddarth's Handbook of Laboratory and Diagnostic Tests. Washington D.C.: American Society of Hematology c2017.

Low hematocrit and hemoglobin and nutritional deficit